PRODUCTS IN DEVELOPMENT

Brazzein is a natural high-intensity sweet protein, from the tropical fruit of Pentadiplandra brazzeana, expressed in maize [1]. The brazzein protein is 500 to 2,000 times sweeter than sucrose and is highly stable. It is  a natural sweetener that can be used alone or blended in food or beverages with other sweeteners such as sucrose.

Aprotinin is an animal-free source of recombinant bovine aprotinin expressed in maize [2]. The recombinant product is chemically and functionally equivalent to the native product and can be used in cell culture, research and other non-clinically regulated industries.

141-small-crop VaxZeanHepatitis B Booster Vaccine is an orally-delivered booster vaccine to complement current injected primary vaccines [3-5]. This product is heat stable and can be transported or stored at ambient temperatures for extended periods of time without loss of activity.

References
1. Lamphear, B. et al. Expression of the sweet protein brazzein in maize for production of a new commercial sweetener. Plant Biotechnology Journal, 2005. 3(1): p. 103-114.
2. Zhong, G. et al. Commercial production of aprotinin in transgenic maize seeds. Molecular Breeding, 1999. 5(4): p. 345-356.
3. Hayden, C.A. et al. Production of highly concentrated, heat‐stable hepatitis B surface antigen in maize. Plant Biotechnology Journal, 2012. 10(8): p. 979-984.
4. Hayden, C.A. et al. Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen. Vaccine, 2012. 30(19): p. 2937-2942.
5. Hayden CA et al. (2015). Oral delivery of wafers made from HBsAg-expressing maize germ induces long-term immunological systemic and mucosal responses. Vaccine, 33(25): p. 2881-2886.